Capranico, G.: search on Z-Library

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1

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

Manzo, S. G., Zhou, Z.-L., Wang, Y.-Q., Marinello, J., He, J.-X., Li, Y.-C., Ding, J., Capranico, G., Miao, Z.-H.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

2

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

Rosanna Filosa, Antonella Peduto, Simone Di Micco, Paolo de Caprariis, Michela Festa, Antonello Petrella, Giovanni Capranico, Giuseppe Bifulco

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

3

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

Claudia Sissi, Elisabetta Leo, Stefano Moro, Giovanni Capranico, Annalaura Mancia, Ernesto Menta, A.Paul Krapcho, Manlio Palumbo

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 488 KB

english, 2004

4

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

Giovanni Capranico, Monica Binaschi, M.Evelina Borgnetto, Franco Zunino, Manlio Palumbo

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 184 KB

english, 1997

5

Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line

Supino, R, Mariani, M, Capranico, G, Colombo, A, Parmiani, G

Journal:

British Journal of Cancer

Year:

1988

Language:

english

File:

PDF, 909 KB

english, 1988

6

A comparative study of cellular and molecular pharmacology of doxorubicin and MEN 10755, a disaccharide analogue

Mario Bigioni, Carmela Salvatore, Angela Bullo, Daniela Bellarosa, Elisabetta Iafrate, Fabio Animati, Giovanni Capranico, Cristina Goso, Carlo Alberto Maggi, Graziella Pratesi, Franco Zunino, Stefano

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 328 KB

english, 2001

7

10th Conference on DNA Topoisomerases in therapy

Giuseppe Giaccone, Giovanni Capranico

Journal:

Drug Resistance Updates

Year:

1999

Language:

english

File:

PDF, 122 KB

english, 1999

8

Interaction Model for Anthracycline Activity against DNA Topoisomerase II †

Moro, Stefano, Beretta, Giovanni L., Dal Ben, Diego, Nitiss, John, Palumbo, Manlio, Capranico, Giovanni

Journal:

Year:

2004

Language:

english

File:

PDF, 604 KB

english, 2004

9

DNA topoisomerase-trapping antitumour drugs

Capranico, Giovanni, Zunino, Franco

Journal:

European Journal of Cancer

Year:

1992

Language:

english

File:

PDF, 896 KB

english, 1992

10

A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts

Supino, Rosanna, Polizzi, Donatella, Pavesi, Raffaella, Pratesi, Graziella, Guano, Fulvio, Capranico, Giovanni, Palumbo, Manlio, Sissi, Claudia, Richter, Silvia, Beggiolin, Gino, Menta, Ernesto, Pezzo

Journal:

Year:

2001

Language:

english

File:

PDF, 274 KB

english, 2001

11

Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues

Giuseppe Zagotto, Ambrogio Oliva, Fulvio Guano, Ernesto Menta, Giovanni Capranico, Manlio Palumbo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 402 KB

english, 1998

12

Further insight into the Zn2+-mediated binding of streptonigrin to DNA

Michele Marcazzan, Barbara Gatto, Claudia Sissi, Giuseppe Zagotto, Giovanni Capranico, Manlio Palumbo

Journal:

Year:

1998

Language:

english

File:

PDF, 133 KB

english, 1998

13

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

Giovanni Capranico, Monica Binaschi, M.Evelina Borgnetto, Franco Zunino, Manlio Palumbo

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 999 KB

english, 1997

14

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase in reconstituted Simian virus 40 chromatin

Capranico, G., Jaxel, C., Roberge, M., Kohn, K. W., Pommier, Y.

Journal:

Nucleic Acids Research

Year:

1990

Language:

english

File:

PDF, 1.19 MB

english, 1990

15

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin

D'Annessa, Ilda, Tesauro, Cinzia, Fiorani, Paola, Chillemi, Giovanni, Castelli, Silvia, Vassallo, Oscar, Capranico, Giovanni, Desideri, Alessandro

Journal:

Journal of Amino Acids

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

16

Influence of structural modifications at the 3' and 4' positions of doxorubicin on the drug ability to trap topoisomerase II and to overcome multidrug resistance

Capranico, G, Supino, R, Binaschi, M, Capolongo, L, Grandi, M, Suarato, a, Zunino, F

Journal:

Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.41 MB

english, 1994

17

RNA G-quadruplexes in Kirsten ras ( KRAS ) oncogene as targets for small molecules inhibiting translation

Miglietta, Giulia, Cogoi, Susanna, Marinello, Jessica, Capranico, Giovanni, Tikhomirov, Alexander S., Shchekotikhin, Andrey E., Xodo, Luigi E.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.22 MB

english, 2017

18

Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung

Giuseppe Giaccone, Jannette van Ark-Otte, Giorgio Scagliotti, Giovanni Capranico, Paul van der Valk, Gonzalo Rubio, Otilia Dalesio, Rafael Lopez, Franco Zunino, Jan Walboomers, Herbert M. Pinedo

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1995

Language:

english

File:

PDF, 1.42 MB

english, 1995

19

ChemInform Abstract: Synthesis, DNA-Damaging and Cytotoxic Properties of Novel Topoisomerase II-Directed Bisantrene Analogues.

G. ZAGOTTO, A. OLIVA, F. GUANO, E. MENTA, G. CAPRANICO, M. PALUMBO

Journal:

Year:

1998

File:

PDF, 32 KB

1998

20

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

Federico Arcamone, Fabio Animati, Mario Bigioni, Giovanni Capranico, Claudia Caserini, Amalia Cipollone, Michelandrea De Cesare, Alessandro Ettorre, Fulvio Guano, Stefano Manzini, Edith Monteagudo, Gr

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 263 KB

english, 1999

21

Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons

M.Evelina Borgnetto, Stella Tinelli, Laura Carminati, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 258 KB

english, 1999

22

[Advances in DNA Sequence-Specific Agents] Volume 3 || Sequence-specific poisons of type II DNA topoisomerases

Capranico, Giovanni

Year:

1998

Language:

english

File:

PDF, 1.84 MB

english, 1998

23

Early Effects of Topoisomerase I Inhibition on RNA Polymerase II Along Transcribed Genes in Human Cells

Andriy Khobta, Francesca Ferri, Luca Lotito, Alessandra Montecucco, Rossella Rossi, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 544 KB

english, 2006

24

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

Zagotto, Giuseppe, Gianoncelli, Alessandra, Sissi, Claudia, Marzano, Cristina, Gandin, Valentina, Pasquale, Riccardo, Capranico, Giovanni, Ribaudo, Giovanni, Palumbo, Manlio

Journal:

Archiv der Pharmazie

Year:

2014

Language:

english

File:

PDF, 485 KB

english, 2014

25

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents

Beretta, Giovanni L., Ribaudo, Giovanni, Menegazzo, Ileana, Supino, Rosanna, Capranico, Giovanni, Zunino, Franco, Zagotto, Giuseppe

Journal:

Archiv der Pharmazie

Year:

2017

Language:

english

File:

PDF, 3.33 MB

english, 2017

26

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

De Magis, Alessio, Manzo, Stefano G., Russo, Marco, Marinello, Jessica, Morigi, Rita, Sordet, Olivier, Capranico, Giovanni

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

27

Comparison of doxorubicin-induced DNA damage in doxorubicin-sensitive and -resistant P388 murine leukemia cells

Giovanni Capranico, Teresa Dasdia, Franco Zunino

Journal:

International Journal of Cancer

Year:

1986

Language:

english

File:

PDF, 465 KB

english, 1986

28

Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug-induced DNA alterations in two human small-cell lung cancer xenografts

G. Pratesi, G. Capranico, M. Binaschi, P. De Isabella, S. Pilotti, R. Supino, F. Zunino

Journal:

International Journal of Cancer

Year:

1990

Language:

english

File:

PDF, 771 KB

english, 1990

29

Enhanced CPT Sensitivity of Yeast Cells and Selective Relaxation of Gal4 Motif-containing DNA by Novel Gal4–Topoisomerase I Fusion Proteins

Marco Alessandri, Giovanni L. Beretta, Edmondo Ferretti, Annalaura Mancia, Andriy Khobta, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.21 MB

english, 2004

30

Eighth conference on DNA topoisomerases and therapy Amsterdam, The Netherlands 15–17 October 1997

Giuseppe Giaccone, Giovanni Capranico

Journal:

Drug Resistance Updates

Year:

1998

Language:

english

File:

PDF, 501 KB

english, 1998

31

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

Capranico, Giovanni, Zunino, Franco, Kohn, Kurt W., Pommier, Yves

Journal:

Year:

1990

Language:

english

File:

PDF, 2.68 MB

english, 1990

32

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

Tonelli, R, Sartini, R, Fronza, R, Freccero, F, Franzoni, M, Dongiovanni, D, Ballarini, M, Ferrari, S, D'apolito, M, Di Cola, G, Capranico, G, Khobta, A, Campanini, R, Paolucci, P, Minucci, S, Pession

Journal:

Year:

2006

Language:

english

File:

PDF, 293 KB

english, 2006

33

Physicochemical properties, cytotoxic activity and topoisomerase ii inhibition of 2,3-diaza-anthracenediones

Paola De Isabella, Manlio Palumbo, Claudia Sissi, Nives Carenini, Giovanni Capranico, Emesto Menta, Ambrogio Oliva, Silvano Spinelli, A.Paul Krapcho, Fernando C. Giuliani, Franco Zunino

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.06 MB

english, 1997

34

Position-Specific Effects of Base Mismatch on Mammalian Topoisomerase II DNA Cleaving Activity †

Bigioni, Mario, Zunino, Franco, Tinelli, Stella, Austin, Caroline A., Willmore, Elaine, Capranico, Giovanni

Journal:

Year:

1996

Language:

english

File:

PDF, 423 KB

english, 1996

35

Preface

Capranico, Giovanni

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 23 KB

english, 2002

36

Mono-hydrazone based G-quadruplex selective ligands induce DNA damage and genome instability in human cancer cells

Amato, Jussara, Miglietta, Giulia, Morigi, Rita, Iaccarino, Nunzia, Locatelli, Alessandra, Leoni, Alberto, Novellino, Ettore, Pagano, Bruno, Capranico, Giovanni, Randazzo, Antonio

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 4.75 MB

2020

37

Comparison of dna cleavage induced by etoposide and doxorubicin in two human small-cell lung cancer lines with different sensitivities to topoisomerase ii inhibitors

Monica Binaschi, Giovanni Capranico, Paola De Isabella, Mariangela Mariani, Rosanna Supino, Stella Tinelli, Franco Zunino

Journal:

International Journal of Cancer

Year:

1990

Language:

english

File:

PDF, 653 KB

english, 1990

38

Novel Symmetric and Asymmetric DNA Scission Determinants for Streptococcus pneumoniae Topoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site

Leo, E., Gould, K. A., Pan, X.-S., Capranico, G., Sanderson, M. R., Palumbo, M., Fisher, L. M.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.11 MB

english, 2005

39

Mapping Drug Interactions at the Covalent Topoisomerase II-DNA Complex by Bisantrene/Amsacrine Congeners

Capranico, G., Guano, F., Moro, S., Zagotto, G., Sissi, C., Gatto, B., Zunino, F., Menta, E., Palumbo, M.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 810 KB

english, 1998

40

DNA-Binding Preferences of Bisantrene Analogues: Relevance to the Sequence Specificity of Drug-Mediated Topoisomerase II Poisoning

Sissi, Claudia, Bolgan, Loretta, Moro, Stefano, Zagotto, Giuseppe, Bailly, Christian, Menta, Ernesto, Capranico, Giovanni, Palumbo, Manlio

Journal:

Molecular Pharmacology

Year:

1998

Language:

english

File:

PDF, 355 KB

english, 1998

41

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

M. Palumbo, M. Mabilia, A. Pozzan, G. Capranico, S. Tinelli, F. Zunino

Journal:

Journal of Molecular Recognition

Year:

1994

Language:

english

File:

PDF, 527 KB

english, 1994

42

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

Francesca Fornari, Maddalena Milazzo, Pasquale Chieco, Massimo Negrini, Elena Marasco, Giovanni Capranico, Vilma Mantovani, Jessica Marinello, Silvia Sabbioni, Elisa Callegari, Matteo Cescon, Matteo R

Journal:

The Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 3.18 MB

english, 2012

43

Global Transcription Regulation by DNA Topoisomerase I in Exponentially Growing Saccharomyces cerevisiae Cells: Activation of Telomere-Proximal Genes by TOP1 Deletion

Luca Lotito, Alessandra Russo, Giovanni Chillemi, Susana Bueno, Duccio Cavalieri, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

44

Inhibitors of mammalian DNA topoisomerases

Giovanni Capranico, Franco Zunino

Journal:

Pharmacological Research

Year:

1995

Language:

english

File:

PDF, 163 KB

english, 1995

45

DNA Topoisomerase I differentially modulates R-loops across the human genome

Manzo, Stefano G., Hartono, Stella R., Sanz, Lionel A., Marinello, Jessica, De Biasi, Sara, Cossarizza, Andrea, Capranico, Giovanni, Chedin, Frederic

Journal:

Year:

2018

Language:

english

File:

PDF, 2.74 MB

english, 2018

46

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

Marinello, Jessica, Delcuratolo, Maria, Capranico, Giovanni

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 552 KB

english, 2018

47

ChemInform Abstract: Anthracyclines: Selected New Developments.

M. Binaschi, M. Bigioni, A. Cipollone, C. Rossi, C. Goso, C. A. Maggi, G. Capranico, F. Animati

Journal:

Year:

2002

File:

PDF, 22 KB

2002

48

Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers

Capranico, Giovanni, Tinelli, Stella, Zunino, Franco, Kohn, Kurt W., Pommier, Yves

Journal:

Year:

1993

Language:

english

File:

PDF, 2.20 MB

english, 1993

49

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide

Pommier, Y., Capranico, G., Orr, A., Kohn, K.W.

Journal:

Nucleic Acids Research

Year:

1991

Language:

english

File:

PDF, 26 KB

english, 1991

50

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

Capranico, Giovanni, Kohn, Kurt W., Pommier, Yves

Journal:

Nucleic Acids Research

Year:

1990

Language:

english

File:

PDF, 1.29 MB

english, 1990

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